|
Inflamm Bowel Dis.
2003 Mar;9(2):116-21. |
|
Increasing
fecal butyrate in ulcerative colitis patients by diet: controlled pilot study.
Hallert C, Bjorck I, Nyman M, Pousette A, Granno C, Svensson H.
Department of Internal
Medicine, Vrinnevi Hospital, Norrkoping, Sweden. Claes.Hallert@lio.se
Topical butyrate has been shown to be effective
in the treatment of ulcerative colitis (UC). Butyrate is derived from colonic fermentation of dietary fiber, and our aim
was to study whether UC patients could safely increase the fecal butyrate level by dietary means. We enrolled 22 patients
with quiescent UC (mean age, 44 years; 45% women; median time from last relapse, 1 year) in a controlled pilot trial lasting
3 months. The patients were instructed to add 60 g oat bran (corresponding to 20 g dietary fiber) to the daily diet, mainly
as bread slices. Fecal short-chain fatty acids (SCFAs) including butyrate, disease activity, and gastrointestinal symptoms
were recorded every 4 weeks. During the oat bran intervention the fecal butyrate concentration increased by 36% at 4 weeks
(from 11 +/- 2 (mean +/- SEM) to 15 +/- 2 micromol/g feces) (p < 0.01). The mean butyrate concentration over the entire
test period was 14 +/- 1 micromol/g feces (p < 0.05). Remaining fecal SCFA levels were unchanged. No patient showed signs
of colitis relapse. Unlike controls, the patients showed no increase in gastrointestinal complaints during the trial. Yet
patients reporting abdominal pain and reflux complaints at entry showed significant improvement at 12 weeks that returned
to baseline 3 months later. This pilot study shows that patients with quiescent UC can safely take a diet rich in oat bran
specifically to increase the fecal butyrate level. This may have clinical implications and warrants studies of the long-term
benefits of using oat bran in the maintenance therapy in UC.
Publication Types:
· Clinical Trial
· Controlled Clinical Trial
PMID:
12769445 [PubMed - indexed for MEDLINE]
|
J Gastroenterol.
2002 Nov;37 Suppl 14:67-72. |
|
Treatment
of ulcerative colitis by feeding with germinated barley foodstuff: first report of a multicenter open control trial.
Kanauchi O, Suga T, Tochihara M, Hibi T, Naganuma M, Homma
T, Asakura H, Nakano H, Takahama K, Fujiyama Y, Andoh A, Shimoyama T, Hida N, Haruma K, Koga H, Mitsuyama K, Sata M, Fukuda
M, Kojima A, Bamba T.
Nutrient Food and Feed Division, Kirin Brewery, 10-1-2 Shinkawa, Chuo-ku, Tokyo 104-8288,
Japan.
BACKGROUND: Germinated barley foodstuff (GBF) is a prebiotic foodstuff that effectively increases luminal butyrate
production by stimulating the growth of protective bacteria. In the first pilot study, GBF has been shown to reduce both clinical
activity and mucosal inflammation in ulcerative colitis (UC). The aim of this study was to investigate the efficacy of GBF
in the treatment of UC in a multicenter open control trial. METHODS: Eighteen patients with mildly to moderately active UC
were divided into two groups using a random allocation protocol. The control group (n = 7) were given a baseline anti-inflammatory
therapy for 4 weeks. In the GBF-treated group (n = 11), patients received 20-30 g GBF daily, together with the baseline treatment,
for 4 weeks. The response to the treatments was evaluated clinically and endoscopically. Fecal microflora were also analyzed.
RESULTS: After 4 weeks of observation, the GBF-treated group showed a significant decrease in clinical activity index scores
compared with the control group (P < 0.05). No side effects related to GBF were observed. GBF therapy increased fecal
concentrations of Bifidobacterium and Eubacterium limosum. CONCLUSIONS: Oral GBF therapy may have the potency to reduce clinical
activity of UC. We believe that these results support the use of GBF administration as a new adjunct therapy for UC.
Publication
Types:
· Clinical Trial
· Multicenter Study
· Randomized Controlled Trial
PMID:
12572869 [PubMed - indexed for MEDLINE]
|
Schweiz Rundsch
Med Prax. 2002 Nov 20;91(47):2041-9. |
|
[Diet therapy in chronic inflammatory bowel disease: results from meta-analysis and randomized
controlled trials]
[Article in German]
Galandi
D, Allgaier HP.
Zentrum Klinische Studien, Universitatsklinikum Freiburg.
BACKGROUND: Crohn's disease and ulcerative
colitis are chronic inflammatory bowel diseases of unknown etiology. Unspecific immunosuppressive therapy represents current
standard treatment and is often associated with severe side effects. Several treatment regimens have been evaluated to identify
alternative therapeutic options. Among these different diet therapies were investigated. Objective of this paper is to review
the results of diet therapy in chronic inflammatory bowel disease on the basis of randomised controlled trials and meta-analysis
of randomised controlled trials. METHODS: Medline and Cochrane Library were searched for meta-analysis and randomised controlled
trials investigating this question. Additionally reference lists of identified articles and text books were checked for further
trials. RESULTS: Four meta-analyses investigated the treatment of acute Crohn's disease with elemental-, semi-elemental-,
and polymeric diets in comparison to corticosteroids or to another form of enteral diet. All meta-analyses show a superiority
of corticosteroids and no difference in the effect of the compared enteral diets. Randomised controlled trials investigating
diet therapy in ulcerative colitis have not been summarised in a meta-analysis yet. Eleven randomised trials were identified
which evaluated diets in ulcerative colitis patients: Dietary supplementation with n-3-fatty acids (6 trials), elemental diet
[2], dietary supplementation with dietary fiber [1], elimination diet [1], and dietary supplementation with olestra [1]. Only
for the elimination diet a significant positive effect on the course of disease was found in one trial which investigated
only 18 patients. CONCLUSIONS: Enteral nutritional therapy of acute Crohn's disease is less effective than treatment with
corticosteroids. In case of severe steroid induced side effects diet treatment can present a promising alternative.
Superiority of one of the investigated different formulations was not found. Meta-analyses of randomised trials provide a
clear and easy to understand presentation of the effect of this intervention. Eleven published trials investigating the
effect of diets in ulcerative colitis show only for elimination diet a positive treatment effect. The trials do find a positive
effect of one of the other interventions but the trials are very small and cannot exclude a treatment effect. Meta-analysis
of these trials would be helpful for a better presentation and understanding of these results.
Publication Types:
· Review
· Review, Tutorial
PMID:
12501499 [PubMed - indexed for MEDLINE]
|
Scand J Gastroenterol.
2002 Apr;37(4):444-9. |
|
Wheat
grass juice in the treatment of active distal ulcerative colitis: a randomized double-blind placebo-controlled trial.
Ben-Arye E, Goldin E, Wengrower D, Stamper A, Kohn R, Berry
E.
Dept. of Family Medicine, The Bruce Rappaport Faculty of Medicine, The Technion, Israel Institute of Technology,
Haifa. eranben@netvision.net.il
BACKGROUND: The use of wheat grass (Triticum aestivum) juice for treatment of various gastrointestinal
and other conditions had been suggested by its proponents for more than 30 years, but was never clinically assessed in a controlled
trial. A preliminary unpublished pilot study suggested efficacy of wheat grass juice in the treatment of ulcerative colitis
(UC). METHODS: A randomized, double-blind, placebo-controlled study. One gastroenterology unit in a tertiary hospital and
three study coordinating centers in three major cities in Israel. Twenty-three patients diagnosed clinically and sigmoidoscopically
with active distal UC were randomly allocated to receive either 100 cc of wheat grass juice, or a matching placebo, daily
for 1 month. Efficacy of treatment was assessed by a 4-fold disease activity index that included rectal bleeding and number
of bowel movements as determined from patient diary records, a sigmoidoscopic evaluation, and global assessment by a physician.
RESULTS: Twenty-one patients completed the study, and full information was available on 19 of them. Treatment with wheat
grass juice was associated with significant reductions in the overall disease activity index (P=0.031) and in the severity
of rectal bleeding (P = 0.025). No serious side effects were found. Fresh extract of wheat grass demonstrated a
prominent tracing in cyclic voltammetry methodology, presumably corresponding to four groups of compounds that exhibit anti-oxidative
properties. CONCLUSION: Wheat grass juice appeared effective and safe as a single or adjuvant treatment of active distal
UC.
Publication Types:
· Clinical Trial
· Multicenter Study
· Randomized Controlled Trial
PMID:
11989836 [PubMed - indexed for MEDLINE]
|
Altern Ther Health
Med. 2000 Jan;6(1):55-63. |
|
Nutritional
therapies for ulcerative colitis: literature review, chart review study, and future research.
Edman JS, Williams WH, Atkins RC.
Hunter College, City University of
New York, USA.
Few clinical studies suggest a significant influence of diet or nutritional supplementation on ulcerative
colitis. One reason is that ulcerative colitis, like many chronic diseases, is multifactorial. This article will describe
and review the relevant literature on ulcerative colitis, including studies of (1) diet and intravenous therapy, (2) nutritional
status and nutritional supplementation, and (3) bowel flora and immune function and their influences. Also, results of a retrospective
chart review study that was done at a complementary medicine office will be presented. Finally, suggestions for future research
will be discussed based on a nutritional model of ulcerative colitis. Taken together, it is hoped that these areas will clarify
the current status of ulcerative colitis research and promote the types of investigations that are necessary to establish
the validity of nutritional influences on ulcerative colitis as well as the mechanisms that are involved.
Publication
Types:
· Review
· Review, Tutorial
PMID:
10631823 [PubMed - indexed for MEDLINE]
An Med Interna.
2004 Mar;21(3):138-42.
[Olive oil:
influence and benefits on some pathologies]
[Article
in Spanish]
Zamora Ardoy
MA, Banez Sanchez F, Banez Sanchez C, Alaminos Garcia P.
Servicio
de Farmacia Hospitalaria, Hospital La Inmaculada, Huercal-Overa, Almeria. pacoba@supercable.es
The olive
tree has been one of the agriculture bases in Mediterranean countries with a great economic and social significance. The oil
derivative from it fruit can be classified in different kinds according with their quality, being the highest exponent the
so-called pure olive oil that contribute in unquestionable benefits for the maintenance of health, illness prevention as well
as a better evolution when the illness is present. There are some studies that prove these benefits in pathologies like cancer
specially breast and stomach cancer (colon, endometrium and ovary cancer too). Gastrointestinal pathology like peptic ulcer,
cholelithiasis and gastric mobility. Rheumatoid arthritis decreasing it development risk and improving it evolution. Diabetes
mellitus increasing insulin sensibility and decreasing blood pressure and atherogenic lipoprotein.
Publication
Types:
Review
Review, Tutorial
PMID: 15043496
[PubMed - indexed for MEDLINE]
